TITLE

Assistant Professor In Residence, Pediatrics and Internal Medicine

EDUCATION/TRAINING

EXPERIENCE & PROFESSIONAL APPOINTMENTS

• 1976 Undergraduate Research Intern, Tumor Immunology, National Institutes of Health, NCI
• 1978-1979 Undergraduate Research Assistant, Experimental Hematology, Radiobiology Laboratory, U.C. Davis
• 1979-1981 X-ray crystallographic analysis, Beck Analytical Services, Bloomington, IN
• 1986-1990 Intern and Resident, Internal Medicine, ABIM Clinical Investigator Pathway, University of California, Davis
• 1994-1997 Clinical Fellow, Biochemical Genetics and Metabolism, University of California, San Diego
• 1996-Present Founder and Co-director, The Mitochondrial and Metabolic Disease Center (MMDC)
• 1998-Present Founder and Co-director, The Molecular Diagnostic Laboratory, MMDC
• 1999-Present Co-founder and Acting Program Director,  The Mitochondrial Medicine Society (MMS)
• 1999-Present Scientific Advisory Board, United Mitochondrial Disease Foundation (UMDF)
• 1999-Present Associate Editor, Mitochondrion
• 2002-Present North American Councilor, The Mitochondrial Medicine Society
• 1997-Present Assistant Professor In Residence, Department of Medicine, Medical Genetics, Biochemical Genetics and Metabolism, University of California, San Diego, School of Medicine
• 2001-Present Assistant Professor In Residence, Department of Pediatrics, Biochemical Genetics and Metabolism, University of California, San Diego, School of Medicine
  Honors and Awards
• 1982-1986 E.B. Rinker Scholarship for Academic Achievement and Teaching, Indiana University School of Medicine
• 1986 Alpha Omega Alpha Medical Honor Society, Graduating with Highest Distinction, Indiana University SOM
• 1987-1989 Medical Scholars Program, University of California, Davis School of Medicine
• 1988 Giannini-Bank of America Award for Medical Research, University of California, Davis
• 1990 National Medical Resident of the Year, Internal Medicine, National Inst. of Health, NIDDK, Bethesda, MD
• 1990-1994 George H. Hewitt Foundation Medical Research Scholar, The Salk Institute, La Jolla, CA
• 1997 Les Arcs Plenary Speaker, Geochemistry and the Metabolic Origins of Microbial Life, 28th Annual Joint International Conference on Evolutionary Biology and High Energy Physics, Les Arcs, France
• 1997-2000 Lennox Foundation Career Development Award, Mitochondrial and Metabolic Disease Research, University of California, San Diego
• 2000-2002 Mallinckrodt Foundation Award, Mitochondrial Research, University of California, San Diego
• 2001 Kelsey Wright Award for Scientific Excellence in Mitochondrial Research, Mitochondria 2001 International Symposium, San Diego, CA
• 2002-Present   Congressional National Leadership Award, United States Congress, Washington, DC
• 2002-Present   California State Honorary Chairman, Congressional Business Advisory Council, Appointed by the Majority Whip of the United States House, Tom DeLay

Federal Government and Public Advisory Committee Service

• 1999 Site Visit Member and Program Project Reviewer, National Institute of Child Health and Human Development
• 2000 National Advisory Panel, Mitochondrial Toxicity Meeting, Forum for Collaborative HIV Research, Center of Health Services Research and Policy,  The George Washington University Medical Center, Washington, D.C.
• 2000 Research Expansion Project, Oversight Committee, The United Mitochondrial Disease Foundation
• 2001-2002 Site Visit Member and Reviewer, Multi-center Clinical Trials Consortium Grant, NICHD
• 2002 Advisory Council member, mitochondrial biology, US Food and Drug Administration (FDA), Biological Response Modifiers Advisory Committee

REPRESENTATIVE PUBLICATIONS (of over 40 Publications)

1. Dai Y, Roman M, Naviaux RK, Verma IM.  Nov 1992.  Gene therapy via primary myblasts: long-term expression of factor IX protein following transplantation in vivo. Proceedings of the National Academy of Sciences of the United States of America 89:10892-10895.

2. Fakhrai H, Shawler DL, Gjerset R, Naviaux RK, Koziol J, Royston I, Sobol RE.  May 1995.  Cytokine gene therapy with interleukin-2-transduced fibroblasts: effects of IL-2 dose on anti-tumor immunity.  Human Gene Therapy. 6:591-601.

3. Naviaux RK, Costanzi E, Haas M, Verma IM.  Aug 1996.  The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses.  Journal of Virology. 70: 5701-5705.

4. Solbrig MV, Naviaux RK.  1997.  Review of the neurology and biology of Ebola and Marburg virus infections.  Neurologic Infections and Epidemiology. 2:5-12.

5. Costanzi-Strauss E, Strauss BE, Naviaux RK, Haas M.  Jan 1998.  Restoration of growth arrest by p16INK4, p21WAF1, pRB, and p53 is dependent on the integrity of the endogenous cell-cycle control pathways in human glioblastoma cell lines.  Experimental Cell Research. 238:51-62.

6. Naviaux, R. K., Nasirian F., Barshop, B. A., Nyhan, W. L. & Haas, R. H. (1996).  The role of reverse transcription in the replication of mitochondrial DNA (Abstract).  Annual meeting of the Society for Inherited Metabolic Disorders.

7. Naviaux, R. K., Barshop, B. A., Nyhan, W. L. & Haas, R. H. (1996). Reverse transcription and the bipotential replication of mitochondrial DNA (Abstract). Annals of Neurology 40:295.

8. Naviaux, R. K., Barshop, B. A., Nyhan, W. L. & Haas, R. H. (1996).  Pararetrovirus-like replication of mitochondrial DNA (Abstract).  Cold Spring Harbor Retrovirus Meeting.

9. Naviaux RK, Nyhan WL, Barshop BA, Poulton J, Markusic D, Karpinski NC, Haas RH.  Jan 1999.  Mitochondrial DNA polymerase gamma deficiency and mtDNA depletion in a child with Alpers syndrome.  Annals of Neurology. 45:54-58.

10. Naviaux RK, Markusic D, Barshop BA, Nyhan WL, Haas RH.  1999.  Sensitive assay for mitochondrial DNA polymerase gamma.  Clin Chem 45:1725-1733.

11. Graf WD, Marin-Garcia J, Gao HG, Pizzo S, Naviaux RK, Markusic D, Barshop BA, Courchesne E, Haas RH. Autism associated with the mtDNA G8363A tRNA lysine mutation.  J Child Neurol 2000;15:357-361.

12. Barshop BA, Nyhan WL, Naviaux RK, McGowan KA, Friedlander M, and Haas RH. Kearns-Sayre syndrome presenting as 2-oxoadipic aciduria, Molecular Genetics and Metabolism 69: 64-68, 2000.

13. Naviaux RK.  2000.  Mitochondrial DNA Disorders.  European J  Pediatrics 159:S219-S226.

14. Naviaux RK.  2000.  Options and challenges in the treatment of mitochondrial disease. Genetics and Medicine 2:56.

15. Scaglia F, Sutton VR, Vogel H, Naviaux RK, Vladutiu G, Bodamer AF, Shapira S.  Mitochondrial DNA depletion associated with partial complex II and IV deficiencies and 3-methylglutaconic aciduria.  J Child Neurol 16(2):136-138, 2001.

16. Bodman, M; Smith, D; Nyhan, WL; Naviaux, RK.  Medium-chain acyl coenzyme A dehydrogenase deficiency: occurrence in an infant and his father. Archives of Neurology  58(5):811-814, 2001.

17. Naviaux RK. 2001. The coding problem-why no one can die of mitochondrial disease in America.  Mitochondrion 1:99 (A34), 2001.

18. Naviaux RK. 2001.  Is animal cell mitochondrial DNA the relic of a Precambrian phage?  A Protovirus hypothesis.  Mitochondrion 1:108 (A58), 2001.

19. Spruijt L, Naviaux RK, McGowan KA, Nyhan WL, Sheean G, Haas RH, Barshop BA.  Nerve conduction changes in patients with mitochondrial diseases treated with dichloroacetate.  Muscle and Nerve  24:916-924, 2001.

20. Naviaux RK, Singh KK.  Ooplasmic transfer and the mitochondrial germ line (correspondence).  Nature 413:347, 2001.

21. Edmonds J, Kirse DJ, Kearns D, Deutsch R, Spruijt L, Naviaux RK.  The otolaryngological manifestations of mitochondrial disease and the risk of neurodegeneration with infection.  Arch Otolaryngol Head Neck Surg 128:355-362, 2002.

22. Nyhan WL, Khanna A, Barshop BA, Naviaux RK, Lavine JE, Hart M, Haas RH. Pyruvate carboxylase deficiency-insights from liver transplantation. Mol Genet Metab 2002 Sep;77(1-2):143.

23. McGowan KA, Nyhan WL, Barshop BA, Naviaux RK, Yu A, Haas RH, Townsend JJ.  The role of methionine in Ethylmalonic Encephalopathy with petechiae.  Arch Neurol,  In Press, 2002.

INVITED REVIEWS & BOOK CHAPTERS

1. Naviaux RK.  The spectrum of mitochondrial disease, in Mitochondrial and Metabolic Disorders-a primary care physician's guide. Psy-Ed Corp., Oradell, NJ, pp. 3-10, 1997.

2. Naviaux RK.  The mitochondrial DNA depletion syndromes: mitochondrial DNA polymerase deficiency , in Atlas of Metabolic Diseases, Nyhan WL (ed), Chapman & Hall, London, pp. 314-320, 1998.

3. Naviaux RK, Nyhan WL.  Galactosemia, in Cecil's Textbook of Medicine, 21st edition, 2000, pp1084-1086.

4. Naviaux RK.  2000.  Adult presentations of mitochondrial disease.  United Mitochondrial Disease Foundation Newsletter 5(March):1-14.

5. Naviaux RK, McGowan KA.  2000.  Organismal effects of mitochondrial dysfunction.  Human Reproduction 15(Suppl 2):44-56.

6. Naviaux RK.  Assay of mitochondrial DNA polymerase gamma from human tissues, in Copeland W (ed) Methods in Molecular Biology, vol 197.  Mitochondrial DNA:  Methods and Protocols, Humana Press Inc., Totowa, NJ  2002.  pp. 259-271.